Analysis Tools
immune system
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• MOG-treated mice exhibit a modest reduction in disease compared with wild-type mice
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Allele Symbol Allele Name Allele ID |
Gpr174tm1Cys targeted mutation 1, Jason G Cyster MGI:5644336 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• MOG-treated mice exhibit a modest reduction in disease compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in mice treated with diphtheria toxin and MOG
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• mice exhibit normal numbers of naive T and B cells, lymphoid tissue organization and T or B cell trafficking
• mice exhibit normal frequencies of T reg cells in the spleen and lymph nodes
• Th17 differentiation is normal
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• LysoPS-treated T cells continue to proliferate unlike wild-type cells
• however, OT-II T cells exhibit proliferation after immunization with ovalbumin in alum adjuvant
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• reduced differentiation even in the absence of exogenous LysoPS
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• increased frequency of Foxp3+ CD4 single positive cells in the thymus and in the colon lamina propria
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• CD103- regulatory T cells more potently suppress anti-CD3 and dendritic cell-induced proliferation compared with wild-type cells
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• MOG-treated mice exhibit decreased peak disease severity with elevated frequency of CD103+ T reg cells in draining lymph nodes at day 8 to 12 compared with wild-type mice
• however, disease onset is normal
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• LysoPS-treated T cells continue to proliferate unlike wild-type cells
• however, OT-II T cells exhibit proliferation after immunization with ovalbumin in alum adjuvant
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• reduced differentiation even in the absence of exogenous LysoPS
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• increased frequency of Foxp3+ CD4 single positive cells in the thymus and in the colon lamina propria
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• CD103- regulatory T cells more potently suppress anti-CD3 and dendritic cell-induced proliferation compared with wild-type cells
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• LysoPS-treated T cells continue to proliferate unlike wild-type cells
• however, OT-II T cells exhibit proliferation after immunization with ovalbumin in alum adjuvant
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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