All Phenotypes Malt1<m1Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Malt1^m1Btlr
mutation 1, Bruce Beutler
MGI:5640788

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Malt1^m1Btlr/Malt1^m1Btlr	C57BL/6J-Malt1^m1Btlr	MGI:5641238
ht2	Malt1^m1Btlr/Malt1⁺	C57BL/6J-Malt1^m1Btlr	MGI:5641239

Allelic Composition	Malt1^m1Btlr/Malt1^m1Btlr
Genetic Background	C57BL/6J-Malt1^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Malt1^m1Btlr mutation (0 available); any Malt1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired humoral immune response ( J:221474 )

• mice show a diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide, a diminished T-dependent antibody response to Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal), and a diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

Allelic Composition	Malt1^m1Btlr/Malt1⁺
Genetic Background	C57BL/6J-Malt1^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Malt1^m1Btlr mutation (0 available); any Malt1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired humoral immune response ( J:221474 )

• mice exhibited diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) compared to wild-type, but not as severe as homozygote

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