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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccr7m1Btlr
mutation 1, Bruce Beutler
MGI:5640785
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccr7m1Btlr/Ccr7m1Btlr C57BL/6J-Ccr7m1Btlr MGI:5641222
ht2
 		Ccr7m1Btlr/Ccr7+ C57BL/6J-Ccr7m1Btlr MGI:5641223


Genotype
MGI:5641222
hm1
Allelic
Composition		 Ccr7m1Btlr/Ccr7m1Btlr
Genetic
Background		 C57BL/6J-Ccr7m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr7m1Btlr mutation (0 available); any Ccr7 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased single-positive T cell number ( J:221477 )
• mice exhibit an increase in the CD4+ to CD8+ T cell ratio in the peripheral blood caused by an increased frequency of CD4+ T cells
decreased macrophage cell number ( J:221477 )
• some mice also exhibited a reduced frequency of macrophages in the peripheral blood

immune system
increased single-positive T cell number ( J:221477 )
• mice exhibit an increase in the CD4+ to CD8+ T cell ratio in the peripheral blood caused by an increased frequency of CD4+ T cells
decreased macrophage cell number ( J:221477 )
• some mice also exhibited a reduced frequency of macrophages in the peripheral blood




Genotype
MGI:5641223
ht2
Allelic
Composition		 Ccr7m1Btlr/Ccr7+
Genetic
Background		 C57BL/6J-Ccr7m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr7m1Btlr mutation (0 available); any Ccr7 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased macrophage cell number ( J:221477 )
• some mice also exhibited a reduced frequency of macrophages in the peripheral blood

immune system
decreased macrophage cell number ( J:221477 )
• some mice also exhibited a reduced frequency of macrophages in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory