Analysis Tools
endocrine/exocrine glands
| N |
• under normal conditions, mice are normoglycemic and show no differences in glucose tolerance, islet size or islet number relative to wild-type controls
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• after 24-h culture in serum-free medium, 53% of mutant pancreatic beta cells undergo apoptosis versus 38% of wild-type cells
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• after 24-h culture in serum-free medium, >25% of mutant islets lose their integrity (defined as 50% loss of the capsule surrounding the islets) and disintegrate relative to less than 5% of wild-type islets
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• after 24-h culture in serum-free medium, mutant islets show a significantly lower ratio of high glucose- versus low glucose-stimulated insulin release than wild-type islets
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homeostasis/metabolism
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• after 24-h culture in serum-free medium, mutant islets show a significantly lower ratio of high glucose- versus low glucose-stimulated insulin release than wild-type islets
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• mice are more susceptible to multiple low-dose streptozotocin (STZ)-induced diabetes than wild-type controls, as determined by blood glucose levels and % of mice that reach normoglycemia from day 6 to day 34 after STZ treatment
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cellular
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• after 24-h culture in serum-free medium, 53% of mutant pancreatic beta cells undergo apoptosis versus 38% of wild-type cells
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growth/size/body
| N |
• contrary to expectation, mice are overtly normal with no obvious differences in body size relative to wild-type controls
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