Phenotypes associated with this allele

• Allele Symbol: Magoh^{tm1c(KOMP)Dlsi}
• Allele Name: targeted mutation 1c, Debra L Silver
• Allele ID: MGI:5638555
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Magoh^tm1c(KOMP)Dlsi/Magoh^tm1c(KOMP)Dlsi	B6J(C3)-Magoh^tm1c(KOMP)Dlsi	MGI:5695281
cn2	Magoh^tm1c(KOMP)Dlsi/Magoh^+ Emx1^tm1(cre)Krj/Emx1^+	B6.Cg-Magoh^tm1c(KOMP)Dlsi Emx1^tm1(cre)Krj	MGI:5695285
cn3	Emx1^tm1(cre)Krj/Emx1^+ Magoh^tm1c(KOMP)Dlsi/Magoh^+	involves: 129S2/SvPas * C57BL/6J	MGI:7335202

Genotype
MGI:5695281

hm1

• Allelic Composition: Magoh^{tm1c(KOMP)Dlsi}/Magoh^{tm1c(KOMP)Dlsi}
• Genetic Background: B6J(C3)-Magoh^{tm1c(KOMP)Dlsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:213515 )

• homozygotes are viable and fertile with no overt phenotype

• no microcephalic phenotype is observed

Genotype
MGI:5695285

cn2

• Allelic Composition: Magoh^{tm1c(KOMP)Dlsi}/Magoh⁺; Emx1^tm1(cre)Krj/Emx1⁺
• Genetic Background: B6.Cg-Magoh^{tm1c(KOMP)Dlsi} Emx1^tm1(cre)Krj

nervous system

decreased brain size ( J:213515 )

• at P12, mutant mice exhibit significantly smaller brains than heterozygous Emx1^tm1(cre)Krj control mice

thin cerebral cortex ( J:213515 )

• at E16.5, cortical thickness is significantly reduced relative to wild-type controls, but thicker than in mice heterozygous for the Magoh^Mos2 allele (likely due to a contribution of ventrally derived neurons which migrate into the dorsal telencephalon, but are not targeted by Emx1-Cre)

Genotype
MGI:7335202

cn3

• Allelic Composition: Emx1^tm1(cre)Krj/Emx1⁺; Magoh^{tm1c(KOMP)Dlsi}/Magoh⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

growth/size/body

microcephaly ( J:235650 )

• in P12 mice