All Phenotypes Ruvbl1<tm1.2Oxbk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ruvbl1^tm1.2Oxbk
targeted mutation 1.2, Oxana Bereshchenko
MGI:5638545

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ruvbl1^tm1.2Oxbk/Ruvbl1^tm1.2Oxbk	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL	MGI:5762862

Allelic Composition	Ruvbl1^tm1.2Oxbk/Ruvbl1^tm1.2Oxbk
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ruvbl1^tm1.2Oxbk mutation (0 available); any Ruvbl1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:220926 )

• no homozygous mutant embryos are retrieved past the blastocyst stage

embryo

decreased inner cell mass proliferation ( J:220926 )

• proliferation of the pluripotent inner cell mass is impaired

abnormal blastocyst formation ( J:220926 )

• only a few blastocysts are identified at E3.5

• upon culture, outgrowth of pluripotent inner mass cells from mutant blastocysts is not achieved

cellular

decreased inner cell mass proliferation ( J:220926 )

• proliferation of the pluripotent inner cell mass is impaired

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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