Phenotypes associated with this allele

• Allele Symbol: Ruvbl1^tm1.2Oxbk
• Allele Name: targeted mutation 1.2, Oxana Bereshchenko
• Allele ID: MGI:5638545
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ruvbl1^tm1.2Oxbk/Ruvbl1^tm1.2Oxbk	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL	MGI:5762862

Genotype
MGI:5762862

hm1

• Allelic Composition: Ruvbl1^tm1.2Oxbk/Ruvbl1^tm1.2Oxbk
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:220926 )

• no homozygous mutant embryos are retrieved past the blastocyst stage

embryo

decreased inner cell mass proliferation ( J:220926 )

• proliferation of the pluripotent inner cell mass is impaired

abnormal blastocyst formation ( J:220926 )

• only a few blastocysts are identified at E3.5

• upon culture, outgrowth of pluripotent inner mass cells from mutant blastocysts is not achieved

cellular

decreased inner cell mass proliferation ( J:220926 )

• proliferation of the pluripotent inner cell mass is impaired