Phenotypes associated with this allele

• Allele Symbol: Chrnb2^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5637195
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrnb2^tm1b(EUCOMM)Hmgu/Chrnb2^tm1b(EUCOMM)Hmgu	C57BL/6N-Chrnb2^tm1b(EUCOMM)Hmgu/H	MGI:5756876
ht2	Chrnb2^tm1b(EUCOMM)Hmgu/Chrnb2^+	C57BL/6N-Chrnb2^tm1b(EUCOMM)Hmgu/H	MGI:5759148

Genotype
MGI:5756876

hm1

• Allelic Composition: Chrnb2^{tm1b(EUCOMM)Hmgu}/Chrnb2^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Chrnb2^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0739_7_H05

Data Sources

IMPC Data for Chrnb2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

♂

IMPC - HAR

cardiovascular system

enlarged heart ( J:211773 )

♂

IMPC - HAR

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - HAR

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - HAR

reproductive system

abnormal epididymis morphology ( J:211773 )

♂

IMPC - HAR

Genotype
MGI:5759148

ht2

• Allelic Composition: Chrnb2^{tm1b(EUCOMM)Hmgu}/Chrnb2⁺
• Genetic Background: C57BL/6N-Chrnb2^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0739_7_H05

Data Sources

IMPC Data for Chrnb2

homeostasis/metabolism

increased circulating aspartate transaminase level ( J:211773 )

♂

IMPC - HAR