Phenotypes associated with this allele

• Allele Symbol: Otud6b^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5637064
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otud6b^tm1b(EUCOMM)Wtsi/Otud6b^tm1b(EUCOMM)Wtsi	C57BL/6N-Otud6b^tm1b(EUCOMM)Wtsi	MGI:5896978
hm2	Otud6b^tm1b(EUCOMM)Wtsi/Otud6b^tm1b(EUCOMM)Wtsi	C57BL/6N-Otud6b^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5757464
ht3	Otud6b^tm1b(EUCOMM)Wtsi/Otud6b^+	C57BL/6N-Otud6b^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5887465

Genotype
MGI:5896978

hm1

• Allelic Composition: Otud6b^{tm1b(EUCOMM)Wtsi}/Otud6b^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Otud6b^{tm1b(EUCOMM)Wtsi}
• Cell Lines: EPD0016_2_H08

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:240669 )

• homozygotes die between E18.5 and shortly after birth

growth/size/body

decreased fetal size ( J:240669 )

• microcomputed tomography revealed that fetuses are smaller than normal at E18.5; however, the 34% reduction in embryo volume is not significant

cardiovascular system

ventricular septal defect ( J:240669 )

• ventricular septal defects (VSDs) are detected in 80% of mutant hearts (3 of 3 hearts at E14.5 and 1 of 2 hearts at E18.5) relative to 0.67% in wild-type hearts

Genotype
MGI:5757464

hm2

• Allelic Composition: Otud6b^{tm1b(EUCOMM)Wtsi}/Otud6b^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Otud6b^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0016_2_H08

Data Sources

IMPC Data for Otud6b

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:5887465

ht3

• Allelic Composition: Otud6b^{tm1b(EUCOMM)Wtsi}/Otud6b⁺
• Genetic Background: C57BL/6N-Otud6b^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0016_2_H08

Data Sources

IMPC Data for Otud6b

hematopoietic system

increased basophil cell number ( J:211773 )

♂

IMPC - HAR

immune system

increased basophil cell number ( J:211773 )

♂

IMPC - HAR