Phenotypes associated with this allele

• Allele Symbol: Ddx42^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5637061
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddx42^tm1b(EUCOMM)Wtsi/Ddx42^tm1b(EUCOMM)Wtsi	C57BL/6N-Ddx42^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5756978
ht2	Ddx42^tm1b(EUCOMM)Wtsi/Ddx42^+	C57BL/6N-Ddx42^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5797470

Genotype
MGI:5756978

hm1

• Allelic Composition: Ddx42^{tm1b(EUCOMM)Wtsi}/Ddx42^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Ddx42^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0769_1_B07

Data Sources

IMPC Data for Ddx42

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal chorion morphology ( J:261316 )

• unpatterned chorion

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment

• biased differentiation (diploid/polyploid trophoblast)

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

embryonic lethality during organogenesis, complete penetrance ( J:261316 )

• lethality at E9.5-E10.5

Genotype
MGI:5797470

ht2

• Allelic Composition: Ddx42^{tm1b(EUCOMM)Wtsi}/Ddx42⁺
• Genetic Background: C57BL/6N-Ddx42^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0769_1_B07

Data Sources

IMPC Data for Ddx42

homeostasis/metabolism

increased circulating thyroxine level ( J:211773 )

♀

IMPC - WTSI