Phenotypes associated with this allele

• Allele Symbol: Rad9a^{tm1.1(KOMP)Wtsi}
• Allele Name: targeted mutation 1.1, Wellcome Trust Sanger Institute
• Allele ID: MGI:5636951
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rad9a^tm1.1(KOMP)Wtsi/Rad9a^tm1.1(KOMP)Wtsi	C57BL/6N-Rad9a^tm1.1(KOMP)Wtsi/Bay	MGI:5767781
ht2	Rad9a^tm1.1(KOMP)Wtsi/Rad9a^+	C57BL/6N-Rad9a^tm1.1(KOMP)Wtsi/Bay	MGI:5797764

Genotype
MGI:5767781

hm1

• Allelic Composition: Rad9a^{tm1.1(KOMP)Wtsi}/Rad9a^{tm1.1(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Rad9a^{tm1.1(KOMP)Wtsi}/Bay
• Cell Lines: EPD0663_5_A10

Data Sources

IMPC Data for Rad9a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:211773 )

IMPC - BCM

abnormal vitelline vasculature morphology ( J:237214 , J:211773 )

MGI

• yolk sac vasculature is an un-remodeled, primitive plexus (J:237214)

IMPC - BCM (J:211773)

abnormal heart morphology ( J:211773 )

IMPC - BCM

failure of heart looping ( J:237214 )

• the heart tube remains linear without undergoing further looping process compared to the left/right atrium and ventricles that form in controls at E9.5

craniofacial

abnormal pharyngeal arch morphology ( J:211773 )

IMPC - BCM

embryo

abnormal vitelline vasculature morphology ( J:237214 , J:211773 )

MGI

• yolk sac vasculature is an un-remodeled, primitive plexus (J:237214)

IMPC - BCM (J:211773)

abnormal embryo development ( J:237214 , J:211773 )

MGI

• severe developmental defects at E9.5 (J:237214)

IMPC - BCM (J:211773)

abnormal embryo turning ( J:237214 , J:211773 )

MGI

• embryos do not turn at E9.5 (J:237214)

IMPC - BCM (J:211773)

embryonic growth retardation ( J:211773 )

IMPC - BCM

abnormal embryo size ( J:211773 )

IMPC - BCM

decreased embryo size ( J:237214 )

abnormal embryonic tissue morphology ( J:237214 )

• the ventral midgut region remains open at E9.5

• posterior part of the embryo is severely dysmorphic at E9.5

abnormal pharyngeal arch morphology ( J:211773 )

IMPC - BCM

abnormal neural fold morphology ( J:237214 )

• anterior neural folds are still open at E9.5

abnormal neural tube closure ( J:211773 )

IMPC - BCM

abnormal somite shape ( J:211773 )

IMPC - BCM

abnormal visceral yolk sac morphology ( J:211773 )

IMPC - BCM

pale yolk sac ( J:211773 )

IMPC - BCM

abnormal chorioallantoic fusion ( J:211773 )

IMPC - BCM

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - BCM

abnormal embryo size ( J:211773 )

IMPC - BCM

decreased embryo size ( J:237214 )

integument

pallor ( J:211773 )

IMPC - BCM

mortality/aging

embryonic lethality ( J:237214 )

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - BCM

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

nervous system

abnormal neural tube closure ( J:211773 )

IMPC - BCM

abnormal forebrain development ( J:211773 )

IMPC - BCM

abnormal hindbrain development ( J:211773 )

IMPC - BCM

abnormal midbrain development ( J:211773 )

IMPC - BCM

Genotype
MGI:5797764

ht2

• Allelic Composition: Rad9a^{tm1.1(KOMP)Wtsi}/Rad9a⁺
• Genetic Background: C57BL/6N-Rad9a^{tm1.1(KOMP)Wtsi}/Bay
• Cell Lines: EPD0663_5_A10

Data Sources

IMPC Data for Rad9a

vision/eye

abnormal eye anterior chamber depth ( J:211773 )

♀

IMPC - BCM