Phenotypes associated with this allele

• Allele Symbol: Adcy9^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5636912
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adcy9^tm1b(EUCOMM)Wtsi/Adcy9^tm1b(EUCOMM)Wtsi	C57BL/6N-Adcy9^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5756656
ht2	Adcy9^tm1b(EUCOMM)Wtsi/Adcy9^+	C57BL/6N-Adcy9^tm1b(EUCOMM)Wtsi/Wtsi	MGI:5797341

Genotype
MGI:5756656

hm1

• Allelic Composition: Adcy9^{tm1b(EUCOMM)Wtsi}/Adcy9^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Adcy9^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0382_6_B06

Data Sources

IMPC Data for Adcy9

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

absent segment of posterior cerebral artery ( J:239583 )

DMDD

abnormal vertebral artery topology ( J:239583 )

DMDD

additional anastomosis between intracranial vertebral arteries ( J:239583 )

DMDD

absent stapedial artery ( J:239583 )

DMDD

dilated liver sinusoidal space ( J:239583 )

DMDD

abnormal umbilical vein topology ( J:239583 )

DMDD

abnormal ductus venosus valve morphology ( J:239583 )

DMDD

absent ductus venosus valve ( J:239583 )

DMDD

dual inferior vena cava ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

liver hemorrhage ( J:239583 )

DMDD

craniofacial

abnormal temporal bone morphology ( J:239583 )

DMDD

digestive/alimentary system

abnormal small intestine placement ( J:239583 )

DMDD

embryo

abnormal umbilical vein topology ( J:239583 )

DMDD

abnormal Mullerian duct morphology ( J:239583 )

DMDD

abnormal Mullerian duct topology ( J:239583 )

DMDD

abnormal placenta morphology ( J:261316 )

• distorted spongiotrophoblast/labyrinth ratio at E14.5

hearing/vestibular/ear

absent stapedial artery ( J:239583 )

DMDD

homeostasis/metabolism

retropleural edema ( J:239583 )

DMDD

immune system

blood in lymph vessels ( J:239583 )

DMDD

liver/biliary system

dilated liver sinusoidal space ( J:239583 )

DMDD

liver hemorrhage ( J:239583 )

DMDD

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 , J:261316 )

IMPC - WTSI (J:211773)

MGI

• fewer than the expected numbers of mice are seen at P14 (J:261316)

nervous system

absent segment of posterior cerebral artery ( J:239583 )

DMDD

small superior cervical ganglion ( J:239583 )

DMDD

normal phenotype

no abnormal phenotype detected ( J:239583 )

DMDD

respiratory system

abnormal right lung accessory lobe morphology ( J:239583 )

DMDD

skeleton

abnormal temporal bone morphology ( J:239583 )

DMDD

vision/eye

retrolental blood ( J:239583 )

DMDD

Genotype
MGI:5797341

ht2

• Allelic Composition: Adcy9^{tm1b(EUCOMM)Wtsi}/Adcy9⁺
• Genetic Background: C57BL/6N-Adcy9^{tm1b(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0382_6_B06

Data Sources

IMPC Data for Adcy9

homeostasis/metabolism

increased circulating insulin level ( J:211773 )

♂

IMPC - WTSI

decreased circulating chloride level ( J:211773 )

IMPC - WTSI