Phenotypes associated with this allele

• Allele Symbol: Ercc5^{tm2b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 2b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5636892
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ercc5^tm2b(EUCOMM)Hmgu/Ercc5^tm2b(EUCOMM)Hmgu	C57BL/6N-Ercc5^tm2b(EUCOMM)Hmgu/Bay	MGI:6262383
ht2	Ercc5^tm2b(EUCOMM)Hmgu/Ercc5^+	C57BL/6N-Ercc5^tm2b(EUCOMM)Hmgu/Bay	MGI:6394287

Genotype
MGI:6262383

hm1

• Allelic Composition: Ercc5^{tm2b(EUCOMM)Hmgu}/Ercc5^{tm2b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Ercc5^{tm2b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0791_6_A10

Data Sources

IMPC Data for Ercc5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

Genotype
MGI:6394287

ht2

• Allelic Composition: Ercc5^{tm2b(EUCOMM)Hmgu}/Ercc5⁺
• Genetic Background: C57BL/6N-Ercc5^{tm2b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0791_6_A10

Data Sources

IMPC Data for Ercc5

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

IMPC - BCM

decreased hematocrit ( J:211773 )

IMPC - BCM

increased mean corpuscular hemoglobin ( J:211773 )

IMPC - BCM

increased mean corpuscular hemoglobin concentration ( J:211773 )

IMPC - BCM

thrombocytosis ( J:211773 )

IMPC - BCM

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

♂

IMPC - BCM