Analysis Tools
mortality/aging
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• heterozygous intercrosses fail to yield homozygous mutant embryos at E9.5 or later
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Allele Symbol Allele Name Allele ID |
Nipbltm1.2Hpt targeted mutation 1.2, Heiko Peters MGI:5636687 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heterozygous intercrosses fail to yield homozygous mutant embryos at E9.5 or later
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• newborn heterozygotes appear smaller than wild-type controls
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• after weaning, heterozygotes are significantly smaller than wild-type controls
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• at 3 to 8 weeks of age, heterozygotes fed ad libitum consistently weigh less than wild-type controls
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• at E18.5, the body weight of heterozygotes is reduced by 18.5% relative to that of wild-type controls
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• newborn heterozygotes display various skeletal abnormalities
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• newborn heterozygotes display open calvarial foramen
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• 6 of 12 newborn heterozygotes exhibit misalignment of ossification centers in the sternum
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• newborn heterozygotes exhibit formation of bilateral (4/6) or unilateral (2/6) stunted 14th ribs
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• newborn heterozygotes exhibit delayed ossification in the phalangeal bones
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• newborn heterozygotes display open calvarial foramen
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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