Phenotypes associated with this allele

• Allele Symbol: Atp2b2^dfw-i5
• Allele Name: deaf waddler i5
• Allele ID: MGI:5636635
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp2b2^dfw-i5/Atp2b2^dfw-i5	involves: C57BL/6J * CBA/CaJ * DBA/2J	MGI:5696179
ht2	Atp2b2^dfw-i5/Atp2b2^+	involves: C57BL/6J * CBA/CaJ * DBA/2J	MGI:5696182

Genotype
MGI:5696179

hm1

• Allelic Composition: Atp2b2^dfw-i5/Atp2b2^dfw-i5
• Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:220660 )

impaired balance ( J:220660 )

• have trouble staying upright

impaired coordination ( J:220660 )

• cannot remain on a stationary rod

stereotypic behavior ( J:220660 )

head tossing ( J:220660 )

circling ( J:220660 )

hearing/vestibular/ear

abnormal cochlear hair cell stereociliary bundle morphology ( J:220660 )

• considerable disorganization

• frequent missing stereociliary bundles

abnormal hearing physiology ( J:220660 )

decreased threshold for auditory brainstem response ( J:220660 )

• Background Sensitivity: as backcrossing to CBA/CaJ continues responses to low and mid frequencies improves

• high frequency responses remain poor

• a gene effect modifier in addition to Cdh23^ahl apparently present

deafness ( J:220660 )

• completely deaf

nervous system

abnormal cochlear hair cell stereociliary bundle morphology ( J:220660 )

• considerable disorganization

• frequent missing stereociliary bundles

Genotype
MGI:5696182

ht2

• Allelic Composition: Atp2b2^dfw-i5/Atp2b2⁺
• Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

behavior/neurological

behavior/neurological phenotype ( J:220660 )

N • behave as well as controls in swimming and rotarod tests when tested at 33 days of age

hearing/vestibular/ear

abnormal cochlear hair cell stereociliary bundle morphology ( J:220660 )

• some abnormalities and disorganization

• intermediate between homozygotes and controls

nervous system

abnormal cochlear hair cell stereociliary bundle morphology ( J:220660 )

• some abnormalities and disorganization

• intermediate between homozygotes and controls