Phenotypes associated with this allele

• Allele Symbol: Lgr4^{tm1.1(cre/ERT2)Npa}
• Allele Name: targeted mutation 1.1, Novartis Pharma AG
• Allele ID: MGI:5635820
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lgr4^tm1.1(cre/ERT2)Npa/Lgr4^tm1.1(cre/ERT2)Npa	involves: C57BL/6	MGI:5635846
cx2	Lgr4^tm1.1(cre/ERT2)Npa/Lgr4^tm1.1(cre/ERT2)Npa Lgr5^tm1.1(cre/ERT2)Npa/Lgr5^tm1.1(cre/ERT2)Npa	involves: C57BL/6	MGI:5635848

Genotype
MGI:5635846

hm1

• Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:212415 )

prenatal lethality, incomplete penetrance ( J:212415 )

renal/urinary system

renal/urinary system phenotype ( J:212415 )

N • at E16.5, mice exhibit normal kidney cell proliferation

kidney cyst ( J:212415 )

• at E16.5

abnormal glomerular capsule space morphology ( J:212415 )

• ectatic at E16.5

dilated renal tubule ( J:212415 )

• at E16.5

integument

abnormal epidermal stem cell proliferation ( J:212415 )

• at E16.5, mice exhibit reduced epidermal stem cell proliferation compared with wild-type mice

decreased hair follicle number ( J:212415 )

• at E16.5

thin epidermis ( J:212415 )

• at E16.5

abnormal skin development ( J:212415 )

• impaired

digestive/alimentary system

abnormal intestine development ( J:212415 )

• impaired embryonic gut development and intestinal stem cell compartment with loss of markers for +4 cells, goblet cells, enteroendocrine cells and enterocytes

abnormal intestine physiology ( J:212415 )

• at E16.5, crypt cell proliferation is reduced 3-fold and parts of the intestine exhibit signs of necrosis compared with wild-type mice

cellular

abnormal epidermal stem cell proliferation ( J:212415 )

• at E16.5, mice exhibit reduced epidermal stem cell proliferation compared with wild-type mice

growth/size/body

kidney cyst ( J:212415 )

• at E16.5

Genotype
MGI:5635848

cx2

• Allelic Composition: Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa}; Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa}
• Genetic Background: involves: C57BL/6

mortality/aging

perinatal lethality, complete penetrance ( J:212415 )

prenatal lethality, incomplete penetrance ( J:212415 )

integument

abnormal epidermal stem cell proliferation ( J:212415 )

• at E16.5, mice exhibit reduced epidermal stem cell proliferation compared with wild-type mice and Lgr4^{tm1.1(cre/ERT2)Npa} homozygotes

abnormal hair follicle development ( J:212415 )

• at E16.5, hair follicles fail to invaginate from the basal cell layer unlike in Lgr4^{tm1.1(cre/ERT2)Npa} homozygotes

decreased hair follicle number ( J:212415 )

• at E16.5 but no more so than in Lgr4^{tm1.1(cre/ERT2)Npa} homozygotes

thin epidermis ( J:212415 )

• at E16.5 more so than in Lgr4^{tm1.1(cre/ERT2)Npa} homozygotes

abnormal skin development ( J:212415 )

• impaired

renal/urinary system

renal/urinary system phenotype ( J:212415 )

N • at E16.5, mice exhibit normal kidney tubules and Bowmans spaces

decreased kidney cell proliferation ( J:212415 )

• at E16.5, mice exhibit decreased cell proliferation compared with wild-type and single knock-out mice

digestive/alimentary system

abnormal intestine development ( J:212415 )

• impaired embryonic gut development and intestinal stem cell compartment with loss of markers for +4 cells, goblet cells, enteroendocrine cells and enterocytes

abnormal intestine physiology ( J:212415 )

• at E16.5, crypt cell proliferation is reduced and parts of the intestine exhibit necrosis compared with wild-type mice but no more so than in Lgr4^{tm1.1(cre/ERT2)Npa} homozygotes

cellular

abnormal epidermal stem cell proliferation ( J:212415 )

• at E16.5, mice exhibit reduced epidermal stem cell proliferation compared with wild-type mice and Lgr4^{tm1.1(cre/ERT2)Npa} homozygotes

decreased kidney cell proliferation ( J:212415 )

• at E16.5, mice exhibit decreased cell proliferation compared with wild-type and single knock-out mice