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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pold2tm1.1(KOMP)Vlcg
targeted mutation 1.1, Velocigene
MGI:5635267
Summary 2 genotypes


Genotype
MGI:6377017
hm1
Allelic
Composition
Pold2tm1.1(KOMP)Vlcg/Pold2tm1.1(KOMP)Vlcg
Genetic
Background
B6N(Cg)-Pold2tm1.1(KOMP)Vlcg/J
Cell Lines 13729A-H11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold2tm1.1(KOMP)Vlcg mutation (1 available); any Pold2 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although normal blastocysts are recovered at expected Mendelian ratios at E3.5, no embryos or excess resorption sites are observed at E7.5

embryo
• blastocysts fail to hatch from the zona pellucida with apparent cell death after 3 days in culture

cellular
• blastocysts show apparent cell death after 3 days in culture




Genotype
MGI:5767767
hm2
Allelic
Composition
Pold2tm1.1(KOMP)Vlcg/Pold2tm1.1(KOMP)Vlcg
Genetic
Background
C57BL/6N-Pold2tm1.1(KOMP)Vlcg/J
Cell Lines 13729A-H11
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold2tm1.1(KOMP)Vlcg mutation (1 available); any Pold2 mutation (31 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory