All Phenotypes Kif21a<tm3Ece> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kif21a^tm3Ece
targeted mutation 3, Elizabeth C Engle
MGI:5635266

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif21a^tm3Ece/Kif21a^tm3Ece	involves: 129S1/Sv	MGI:6241437
ht2	Kif21a^tm3Ece/Kif21a⁺	involves: 129S1/Sv	MGI:6241438
ht3	Kif21a^tm1.1Ece/Kif21a^tm3Ece	involves: 129S1/Sv * 129S4/SvJae	MGI:6241442

Allelic Composition	Kif21a^tm3Ece/Kif21a^tm3Ece
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif21a^tm3Ece mutation (0 available); any Kif21a mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:213171 )

• mice die within 24 hours of birth

nervous system

nervous system phenotype ( J:213171 )

N	• the developing oculomotor nerve does not contain a bulb or distal thinning and oculomotor nerve neuron apoptosis is similar to wild-type levels

Allelic Composition	Kif21a^tm3Ece/Kif21a⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif21a^tm3Ece mutation (0 available); any Kif21a mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:213171 )

• mice are viable and appear phenotypically normal, with no external congenital fibrosis of the extraocular muscles phenotype

Allelic Composition	Kif21a^tm1.1Ece/Kif21a^tm3Ece
Genetic Background	involves: 129S1/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif21a^tm1.1Ece mutation (0 available); any Kif21a mutation (81 available)
Kif21a^tm3Ece mutation (0 available); any Kif21a mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal extraocular muscle morphology ( J:213171 )

• 22% of mice show an external congenital fibrosis of the extraocular muscles phenotype that is mild

muscle

abnormal extraocular muscle morphology ( J:213171 )

• 22% of mice show an external congenital fibrosis of the extraocular muscles phenotype that is mild

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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