Phenotypes associated with this allele

• Allele Symbol: Nsun5^{tm2b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 2b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5635257
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nsun5^tm2b(EUCOMM)Wtsi/Nsun5^tm2b(EUCOMM)Wtsi	C57BL/6NJ-Nsun5^tm2b(EUCOMM)Wtsi/J	MGI:7414988
hm2	Nsun5^tm2b(EUCOMM)Wtsi/Nsun5^tm2b(EUCOMM)Wtsi	C57BL/6N-Nsun5^tm2b(EUCOMM)Wtsi/J	MGI:6408542

Genotype
MGI:7414988

hm1

• Allelic Composition: Nsun5^{tm2b(EUCOMM)Wtsi}/Nsun5^{tm2b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6NJ-Nsun5^{tm2b(EUCOMM)Wtsi}/J
• Cell Lines: EPD0174_1_G02

Data Sources

IMPC Data for Nsun5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired pupillary reflex ( J:211773 )

IMPC - JAX

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

♀

IMPC - JAX

decreased hematocrit ( J:211773 )

♀

IMPC - JAX

decreased hemoglobin content ( J:211773 )

♀

IMPC - JAX

thrombocytopenia ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

♂

IMPC - JAX

vision/eye

impaired pupillary reflex ( J:211773 )

IMPC - JAX

Genotype
MGI:6408542

hm2

• Allelic Composition: Nsun5^{tm2b(EUCOMM)Wtsi}/Nsun5^{tm2b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nsun5^{tm2b(EUCOMM)Wtsi}/J
• Cell Lines: EPD0174_1_G02

Data Sources

IMPC Data for Nsun5

behavior/neurological

abnormal behavior ( J:211773 )

IMPC - HAR

decreased thigmotaxis ( J:211773 )

IMPC - HAR

decreased locomotor activity ( J:211773 )

IMPC - HAR

cardiovascular system

prolonged QRS complex duration ( J:211773 )

♂

IMPC - HAR

hematopoietic system

increased neutrophil cell number ( J:211773 )

♀

IMPC - HAR

thrombocytopenia ( J:211773 )

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♀

IMPC - HAR

decreased spleen weight ( J:211773 )

♀

IMPC - HAR

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - HAR

immune system

increased neutrophil cell number ( J:211773 )

♀

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♀

IMPC - HAR

decreased spleen weight ( J:211773 )

♀

IMPC - HAR