Phenotypes associated with this allele

• Allele Symbol: Cuedc2^tm1Qxia
• Allele Name: targeted mutation 1, Qing Xia
• Allele ID: MGI:5635142
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cuedc2^tm1Qxia/Cuedc2^tm1Qxia	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:6360705

Genotype
MGI:6360705

hm1

• Allelic Composition: Cuedc2^tm1Qxia/Cuedc2^tm1Qxia
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to induced colitis ( J:211782 )

• mice show increased susceptibility to dextran sodium sulfate (DSS)-induced colitis, showing increased body weight loss, rectal bleeding and diarrhea, shorter colons, massive disruption of colon mucosal structures and thickened walls, and increased colon inflammation compared to wild-type mice

abnormal macrophage physiology ( J:211782 )

• bone marrow derived macrophages treated with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) produce increased amounts of inducible nitric oxide synthase, an M1 marker, but normal amount of arginase 1, a M2 marker, indicating increased M1 macrophage polarization

increased macrophage cytokine production ( J:211782 )

• bone marrow derived macrophages treated with LPS show increased induction of IL-6, TNF-alpha, IL-12, and IL-1beta and higher secretion of IL-6, TNF-alpha, and IL-12

• however, macrophages differentiate normally

neoplasm

increased incidence of tumors by chemical induction ( J:211782 )

• mice treated with azoxymethane (AOM) followed by 3 cycles of DSS show increased tumor number and size in colons, higher tumor loads, and increased weight loss compared to treated wild-type controls

• AOM- and DSS-treated mice show a large increase in adenomas with a higher degree of dysplasia, of which about 50% are classified as severe-grade dysplasia compared to only about 20% in wild-type mice

digestive/alimentary system

increased susceptibility to induced colitis ( J:211782 )

• mice show increased susceptibility to dextran sodium sulfate (DSS)-induced colitis, showing increased body weight loss, rectal bleeding and diarrhea, shorter colons, massive disruption of colon mucosal structures and thickened walls, and increased colon inflammation compared to wild-type mice

hematopoietic system

abnormal macrophage physiology ( J:211782 )

• bone marrow derived macrophages treated with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) produce increased amounts of inducible nitric oxide synthase, an M1 marker, but normal amount of arginase 1, a M2 marker, indicating increased M1 macrophage polarization

increased macrophage cytokine production ( J:211782 )

• bone marrow derived macrophages treated with LPS show increased induction of IL-6, TNF-alpha, IL-12, and IL-1beta and higher secretion of IL-6, TNF-alpha, and IL-12

• however, macrophages differentiate normally

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:211782 )

• mice treated with azoxymethane (AOM) followed by 3 cycles of DSS show increased tumor number and size in colons, higher tumor loads, and increased weight loss compared to treated wild-type controls

• AOM- and DSS-treated mice show a large increase in adenomas with a higher degree of dysplasia, of which about 50% are classified as severe-grade dysplasia compared to only about 20% in wild-type mice