Phenotypes associated with this allele

• Allele Symbol: Ciroz^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5635119
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ciroz^tm1b(EUCOMM)Hmgu/Ciroz^tm1b(EUCOMM)Hmgu	C57BL/6N-Gm572^tm1b(EUCOMM)Hmgu/J	MGI:6262537
ht2	Ciroz^tm1b(EUCOMM)Hmgu/Ciroz^+	C57BL/6N-Gm572^tm1b(EUCOMM)Hmgu/J	MGI:6262536

Genotype
MGI:6262537

hm1

• Allelic Composition: Ciroz^{tm1b(EUCOMM)Hmgu}/Ciroz^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Gm572^{tm1b(EUCOMM)Hmgu}/J
• Cell Lines: HEPD0741_5_G05

Data Sources

IMPC Data for Ciroz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

heterotaxia ( J:363359 )

abdominal situs ambiguus ( J:363359 )

bronchial situs inversus ( J:363359 )

situs ambiguus ( J:363359 )

visceral organ asymmetry ( J:363359 )

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality, incomplete penetrance ( J:363359 )

• fewer than 6% of homozygotes survive to birth

respiratory system

bronchial situs inversus ( J:363359 )

Genotype
MGI:6262536

ht2

• Allelic Composition: Ciroz^{tm1b(EUCOMM)Hmgu}/Ciroz⁺
• Genetic Background: C57BL/6N-Gm572^{tm1b(EUCOMM)Hmgu}/J
• Cell Lines: HEPD0741_5_G05

Data Sources

IMPC Data for Ciroz

behavior/neurological

impaired pupillary reflex ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

♀

IMPC - JAX

vision/eye

impaired pupillary reflex ( J:211773 )

♂

IMPC - JAX