Phenotypes associated with this allele

• Allele Symbol: Dbr1^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5635044
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dbr1^tm1.1(KOMP)Vlcg/Dbr1^tm1.1(KOMP)Vlcg	B6N(Cg)-Dbr1^tm1.1(KOMP)Vlcg/J	MGI:6376465
hm2	Dbr1^tm1.1(KOMP)Vlcg/Dbr1^tm1.1(KOMP)Vlcg	C57BL/6N-Dbr1^tm1.1(KOMP)Vlcg/J	MGI:6262252
ht3	Dbr1^tm1.1(KOMP)Vlcg/Dbr1^+	C57BL/6N-Dbr1^tm1.1(KOMP)Vlcg/J	MGI:6262251

Genotype
MGI:6376465

hm1

• Allelic Composition: Dbr1^{tm1.1(KOMP)Vlcg}/Dbr1^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Dbr1^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 18796A-G12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• normal looking blastocysts are present at slightly lower than expected Mendelian ratios at E3.5 (19% versus 25%); no homozygous embryos or excess resorption sites are observed at E7.5

• however, blastocysts hatch from the zona pellucida and form morphologically typical outgrowth colonies with apparent trophectoderm (TE), primitive endoderm (PrE) and inner cell mass (ICM) after 3 days in culture

Genotype
MGI:6262252

hm2

• Allelic Composition: Dbr1^{tm1.1(KOMP)Vlcg}/Dbr1^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Dbr1^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 18796A-G12

Data Sources

IMPC Data for Dbr1

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6262251

ht3

• Allelic Composition: Dbr1^{tm1.1(KOMP)Vlcg}/Dbr1⁺
• Genetic Background: C57BL/6N-Dbr1^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 18796A-G12

Data Sources

IMPC Data for Dbr1

homeostasis/metabolism

decreased urine magnesium level ( J:211773 )

IMPC - JAX

renal/urinary system

decreased urine magnesium level ( J:211773 )

IMPC - JAX

vision/eye

abnormal lens morphology ( J:211773 )

♀

IMPC - JAX