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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fosbtm2.1Yun
targeted mutation 2.1, Yusaku Nakabeppu
MGI:5634957
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fosbtm2.1Yun/Fosbtm2.1Yun involves: 129S/SvEv * C57BL/6 MGI:5691446
ht2
Fosbtm2.1Yun/Fosb+ involves: 129S/SvEv * C57BL/6 MGI:5691447


Genotype
MGI:5691446
hm1
Allelic
Composition
Fosbtm2.1Yun/Fosbtm2.1Yun
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosbtm2.1Yun mutation (1 available); any Fosb mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• longer time to reach the platform in a Morris water maze although other parameters of performance are normal
• in probe tests, less time is spent in the quadrant where the platform had been than is true for controls
• open field exploratory behavior is greater than controls at day 1
• although exploratory behavior declines by day 3, it remains greater than in controls
• poorer improvement of swim time in a forced swim test than observed in other genotypes than is seen for other genotypes
• spend considerably less time on the open arms of an elevated maze than do controls
• show considerable less locomotor activity than controls when housed alone for 3 days
• difference from controls disappears after being housed alone for one month
• transient hyperlocomotion induced by methylphenidate (MPH)




Genotype
MGI:5691447
ht2
Allelic
Composition
Fosbtm2.1Yun/Fosb+
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosbtm2.1Yun mutation (1 available); any Fosb mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• show somewhat more locomotor activity than controls when housed alone for one month





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory