Phenotypes associated with this allele

• Allele Symbol: Adamts9^Mhdaund4
• Allele Name: Martin Hrabe de Angelis undefined mutation 4
• Allele ID: MGI:5629512
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts9^Mhdaund4/Adamts9^Mhdaund4	involves: C3HeB/FeJ * CAST/EiJ	MGI:6163980
ht2	Adamts9^Mhdaund4/Adamts9^+	C3HeB/FeJ-Adamts9^Mhdaund4	MGI:6163978
cx3	Adamts9^Mhdaund4/Adamts9^+ Tg(Dct-lacZ)A12Jkn/0	involves: C3HeB/FeJ * C57BL/6 * CBA	MGI:6163981

Genotype
MGI:6163980

hm1

• Allelic Composition: Adamts9^Mhdaund4/Adamts9^Mhdaund4
• Genetic Background: involves: C3HeB/FeJ * CAST/EiJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:262498 )

• no mice are recovered at weaning

Genotype
MGI:6163978

ht2

• Allelic Composition: Adamts9^Mhdaund4/Adamts9⁺
• Genetic Background: C3HeB/FeJ-Adamts9^Mhdaund4

pigmentation

abnormal epidermal pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

abnormal tail pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

integument

abnormal epidermal pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

abnormal tail pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

limbs/digits/tail

abnormal tail pigmentation ( J:262498 )

• unpigmented ring of epidermis, but normal dermis pigmentation, in the middle of the tail with less than 100% penetrance and fewer animals exhibiting both dorsal and ventral hypopigmentation

• however, body pigmentation is otherwise normal

Genotype
MGI:6163981

cx3

• Allelic Composition: Adamts9^Mhdaund4/Adamts9⁺; Tg(Dct-lacZ)A12Jkn/0
• Genetic Background: involves: C3HeB/FeJ * C57BL/6 * CBA

pigmentation

abnormal epidermal pigmentation ( J:262498 )

• at P8, over half of mice exhibit an area of reduced melanoblasts in the tail unlike in wild-type mice

• however, distribution of melanoblasts in the dermis is normal

embryo

abnormal melanoblast morphology ( J:262498 )

• at E18.5/P0, all mice exhibit an area of reduced melanoblasts in the tail compared with just over half of wild-type mice

• at P2, most mice exhibit an area of reduced melanoblasts in the tail compared with few wild-type mice

• at P8, over half of mice exhibit an area of reduced melanoblasts in the tail unlike in wild-type mice

• the boundaries of hypopigmentation are stable over time

• at P28, hypopigmented epidermis in the skin contains no lacZ-positive cells in the scales or hair with some scales at the edge being lightly pigmented and containing less dendritic melanocytes

• however, melanoblast distribution in the tail is normal at E16.5 and distribution of melanoblasts in the dermis is normal

integument

abnormal epidermal pigmentation ( J:262498 )

• at P8, over half of mice exhibit an area of reduced melanoblasts in the tail unlike in wild-type mice

• however, distribution of melanoblasts in the dermis is normal

nervous system

abnormal melanoblast morphology ( J:262498 )

• at E18.5/P0, all mice exhibit an area of reduced melanoblasts in the tail compared with just over half of wild-type mice

• at P2, most mice exhibit an area of reduced melanoblasts in the tail compared with few wild-type mice

• at P8, over half of mice exhibit an area of reduced melanoblasts in the tail unlike in wild-type mice

• the boundaries of hypopigmentation are stable over time

• at P28, hypopigmented epidermis in the skin contains no lacZ-positive cells in the scales or hair with some scales at the edge being lightly pigmented and containing less dendritic melanocytes

• however, melanoblast distribution in the tail is normal at E16.5 and distribution of melanoblasts in the dermis is normal