Phenotypes associated with this allele

• Allele Symbol: Ercc2^Mhdarco15
• Allele Name: Martin Hrabe de Angelis reduced coat 15
• Allele ID: MGI:5621284
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ercc2^Mhdarco15/Ercc2^Mhdarco15	C3HeB/FeJ-Ercc2^Mhdarco15	MGI:5661198
ht2	Ercc2^Mhdarco15/Ercc2^+	C3HeB/FeJ-Ercc2^Mhdarco15	MGI:5661199

Genotype
MGI:5661198

hm1

• Allelic Composition: Ercc2^Mhdarco15/Ercc2^Mhdarco15
• Genetic Background: C3HeB/FeJ-Ercc2^Mhdarco15

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:223515 )

♂N • male mice reproduce

female infertility ( J:223515 )

♀

vision/eye

abnormal lens morphology ( J:223515 )

• abnormal cortical-equatorial regions

lens vacuoles ( J:223515 )

• vacuoles at the posterior-subcapsular region at P7

• however, vacuoles decrease in size with age and are almost gone by P14

developmental cataract ( J:223515 )

• cataracts present at birth

nuclear cataract ( J:223515 )

• anterior-nuclear opacity at 5 weeks with ring-like structures observed in isolated lenses

• however, lenses are clear until E17.5 and ring-like structures are not observed in Scheimpflug images

small lens ( J:223515 )

microphthalmia ( J:223515 )

growth/size/body

decreased body size ( J:223515 )

integument

rough coat ( J:223515 )

Genotype
MGI:5661199

ht2

• Allelic Composition: Ercc2^Mhdarco15/Ercc2⁺
• Genetic Background: C3HeB/FeJ-Ercc2^Mhdarco15

homeostasis/metabolism

abnormal response to radiation ( J:223515 )

• gamma-irradiated peripheral lymphocytes exhibit 1.5 times higher DNA damage compared with wild-type cells