About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk4tm1Melo
targeted mutation 1, Sylvain Meloche
MGI:5620956
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapk4tm1Melo/Mapk4tm1Melo B6.129-Mapk4tm1Melo MGI:5621011
cx2
 		Mapk4tm1Melo/Mapk4tm1Melo
Mapk6tm1Melo/Mapk6tm1Melo 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5621012


Genotype
MGI:5621011
hm1
Allelic
Composition		 Mapk4tm1Melo/Mapk4tm1Melo
Genetic
Background		 B6.129-Mapk4tm1Melo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk4tm1Melo mutation (1 available); any Mapk4 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:219480 )
• mice are viable and fertile and exhibit no gross morphological or physiological anomalies




Genotype
MGI:5621012
cx2
Allelic
Composition		 Mapk4tm1Melo/Mapk4tm1Melo
Mapk6tm1Melo/Mapk6tm1Melo
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk4tm1Melo mutation (1 available); any Mapk4 mutation (69 available)
Mapk6tm1Melo mutation (1 available); any Mapk6 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:219480 )
• as in Mapk6tm1Melo homozygotes

growth/size/body
decreased body size ( J:219480 )
• as in Mapk6tm1Melo homozygotes
decreased body weight ( J:219480 )
• as in Mapk6tm1Melo homozygotes

respiratory system
abnormal lung saccule morphology ( J:219480 )
• decreased saccular space as in Mapk6tm1Melo homozygotes
increased type II pneumocyte number ( J:219480 )
• as in Mapk6tm1Melo homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory