Phenotypes associated with this allele

• Allele Symbol: Flnb^skm2
• Allele Name: skeletal morphology mutant 2
• Allele ID: MGI:5620888
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Flnb^skm2/Flnb^skm2	involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J	MGI:5660810

Genotype
MGI:5660810

hm1

• Allelic Composition: Flnb^skm2/Flnb^skm2
• Genetic Background: involves: 129S1/SvImJ * 129X1/SvJ * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:218364 )

• at weaning, only 8 mutants out of 84 progeny are identified (9.5% ratio), suggesting embryonic or perinatal mortality

growth/size/body

decreased body height ( J:218364 )

• after birth, mice are readily identified by their shortened stature

respiratory system

tachypnea ( J:218364 )

• mice exhibit tachypnea, likely as a result of thoracic deformities

behavior/neurological

abnormal gait ( J:218364 )

homeostasis/metabolism

dehydration ( J:218364 )

• mice are dehydrated

skeleton

abnormal thoracic cage morphology ( J:218364 )

• mice exhibit an abnormal thoracic cage with less ribs, a malformed sternum, and fusion of several vertebrae

abnormal sternum morphology ( J:218364 )

decreased rib number ( J:218364 )

thoracic vertebral fusion ( J:218364 )

lordosis ( J:218364 )

• all mice exhibit severe lordosis

scoliosis ( J:218364 )

• all mice exhibit severe scoliosis