About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		ApcM1Tno
Mutation 1, Tetsuo Noda
MGI:5620880
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		ApcM1Tno/ApcM1Tno involves: C57BL/6 * DBA/2JJcl MGI:5688289
ht2
 		ApcM1Tno/Apc+ either: B6JJcl.B6(D2JJcl)-ApcM1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl) MGI:5688288
ht3
 		ApcM1Tno/Apc+ involves: C57BL/6 * DBA/2JJcl MGI:5688286


Genotype
MGI:5688289
hm1
Allelic
Composition		 ApcM1Tno/ApcM1Tno
Genetic
Background		 involves: C57BL/6 * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcM1Tno mutation (0 available); any Apc mutation (154 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:218227 )
• no homozygotes are found at E10.5-E13.5, while embryos are detected at E6.5-E.9.5, indicating lethality between E9.5 and E10.5




Genotype
MGI:5688288
ht2
Allelic
Composition		 ApcM1Tno/Apc+
Genetic
Background		 either: B6JJcl.B6(D2JJcl)-ApcM1Tno or (involves: C57BL/6 * C57BL/6JJcl * DBA/2JJcl)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcM1Tno mutation (0 available); any Apc mutation (154 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:218227 )
• 100% of females but only 10.1% of males develop breast cancers
• breast cancers arise from 2 months of age
increased mammary adenocarcinoma incidence ( J:218227 )
• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features
increased skin tumor incidence ( J:218227 )
• 86.5% of males, but only 12.2% of females, exhibit trichogenic tumors
• trichogenic tumors in males arise from 9 months of age
increased pilomatricoma incidence ( J:218227 )
• trichogenic tumors are trichoepithelioma and pilomatricoma
increased trichoepithelioma incidence ( J:218227 )
• trichogenic tumors are trichoepithelioma and pilomatricoma
increased osteosarcoma incidence ( J:218227 )
• some mice develop bone tumors containing proliferating spindle cells indicating osteosarcomas
increased osteoma incidence ( J:218227 )
• 54.2% of females and 93.3% of males exhibit osteomas
• osteomas are mainly seen in the skulls and mandibular bones, with some in the ribs and scapulas
• osteomas in males arise from 9 months of age

mortality/aging
premature death ( J:218227 )
• females become moribund as early as 9 weeks of age

integument
increased mammary gland tumor incidence ( J:218227 )
• 100% of females but only 10.1% of males develop breast cancers
• breast cancers arise from 2 months of age
increased mammary adenocarcinoma incidence ( J:218227 )
• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features
increased skin tumor incidence ( J:218227 )
• 86.5% of males, but only 12.2% of females, exhibit trichogenic tumors
• trichogenic tumors in males arise from 9 months of age
increased pilomatricoma incidence ( J:218227 )
• trichogenic tumors are trichoepithelioma and pilomatricoma
increased trichoepithelioma incidence ( J:218227 )
• trichogenic tumors are trichoepithelioma and pilomatricoma

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:218227 )
• 100% of females but only 10.1% of males develop breast cancers
• breast cancers arise from 2 months of age
increased mammary adenocarcinoma incidence ( J:218227 )
• breast cancers are adenosquamous carcinoma with ductal structures, invasive foci, and poorly differentiated features

skeleton
increased osteosarcoma incidence ( J:218227 )
• some mice develop bone tumors containing proliferating spindle cells indicating osteosarcomas
increased osteoma incidence ( J:218227 )
• 54.2% of females and 93.3% of males exhibit osteomas
• osteomas are mainly seen in the skulls and mandibular bones, with some in the ribs and scapulas
• osteomas in males arise from 9 months of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
familial adenomatous polyposis DOID:0050424 OMIM:PS175100
 J:218227




Genotype
MGI:5688286
ht3
Allelic
Composition		 ApcM1Tno/Apc+
Genetic
Background		 involves: C57BL/6 * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcM1Tno mutation (0 available); any Apc mutation (154 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:218227 )
• females exhibit multiple breast cancers
increased skin tumor incidence ( J:218227 )
• some mutants of both genders exhibit multiple trichogenic tumors
increased osteoma incidence ( J:218227 )
• males exhibit multiple osteomas

mortality/aging
premature death ( J:218227 )
• 76% of males survive up to 60 weeks of age
• only 50% of females survive up to 50 weeks of age

integument
increased mammary gland tumor incidence ( J:218227 )
• females exhibit multiple breast cancers
increased skin tumor incidence ( J:218227 )
• some mutants of both genders exhibit multiple trichogenic tumors

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:218227 )
• females exhibit multiple breast cancers

skeleton
increased osteoma incidence ( J:218227 )
• males exhibit multiple osteomas




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory