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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nus1tm1.1Wcsa
targeted mutation 1.1, William C Sessa
MGI:5620527
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nus1tm1.1Wcsa/Nus1tm1.1Wcsa involves: 129S4/SvJae MGI:5620601
cn2
 		Nus1tm1Wcsa/Nus1tm1.1Wcsa involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:5620602


Genotype
MGI:5620601
hm1
Allelic
Composition		 Nus1tm1.1Wcsa/Nus1tm1.1Wcsa
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1.1Wcsa mutation (0 available); any Nus1 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:215785 )
• mice are present at E6.5




Genotype
MGI:5620602
cn2
Allelic
Composition		 Nus1tm1Wcsa/Nus1tm1.1Wcsa
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1.1Wcsa mutation (0 available); any Nus1 mutation (19 available)
Nus1tm1Wcsa mutation (0 available); any Nus1 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:215785 )
• tamoxifen-treated mouse embryonic fibroblasts exhibit decreased cis-PTase activity in isolated membranes and mannose incorporation into proteins compared with wild-type cells
increased sensitivity to induced cell death ( J:215785 )
• in tamoxifen-treated mouse embryonic fibroblasts exposed to lovastatin
abnormal cellular cholesterol metabolism ( J:215785 )
• tamoxifen-treated mouse embryonic fibroblasts accumulate free cholesterol compared with control mice

homeostasis/metabolism
abnormal cellular cholesterol metabolism ( J:215785 )
• tamoxifen-treated mouse embryonic fibroblasts accumulate free cholesterol compared with control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory