About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vgftm2(VGF*)Srjs
targeted mutation 2, Stephen R J Salton
MGI:5619978
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vgftm2(VGF*)Srjs/Vgftm2(VGF*)Srjs involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5688364


Genotype
MGI:5688364
hm1
Allelic
Composition		 Vgftm2(VGF*)Srjs/Vgftm2(VGF*)Srjs
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgftm2(VGF*)Srjs mutation (0 available); any Vgf mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:212045 )
N
• homozygotes exhibit normalized SBP, DBP and MAP relative to mice homozygous for the Vgftm1Vlcg allele, indicating rescue of the hypertensive knockout phenotype
• notably, homozygotes exhibit a small but significant increase in SBP relative to mice homozygous for the Vgftm1(VGF)Srjs allele




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory