Phenotypes associated with this allele

• Allele Symbol: Cabp1^tm1Alee
• Allele Name: targeted mutation 1, Amy Lee
• Allele ID: MGI:5618492
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cabp1^tm1Alee/Cabp1^tm1Alee	involves: 129	MGI:6157324
hm2	Cabp1^tm1Alee/Cabp1^tm1Alee	involves: 129 * C57BL/6	MGI:5780462

Genotype
MGI:6157324

hm1

• Allelic Composition: Cabp1^tm1Alee/Cabp1^tm1Alee
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:255928 )

N • morphology of retinal cells, axons and dendrites

abnormal eye electrophysiology ( J:255928 )

• larger and slower response to light flash in retinal OFF transient (OFF T) ganglion cells

• slower response to light flash in retinal OFF sustained (OFF S) ganglion cells

• amplitude of response to light flash in retinal OFF S ganglion cells

• reduction in amplitude of nonlinearity of excitatory synaptic currents in retinal OFF S ganglion cells in response to random noise stimulus

• increase in amplitude of nonlinearity of excitatory synaptic currents in retinal OFF T ganglion cells in response to random noise stimulus

• significantly smaller difference between maximum and minimum excitatory synaptic current evoked by random noise stimulus in retinal OFF S ganglion cells

• significantly larger difference between maximum and minimum excitatory synaptic current evoked by random noise stimulus in retinal OFF T ganglion cells

• stronger spike response to 100% contrast step in retinal OFF T ganglion cells

• response range to random noise stimulus in retinal ON alpha ganglion cells

• slower response kinetics to random noise stimulus in retinal ON alpha ganglion cells

• time to peak and amplitude of b-waves of electroretinograms in response to light stimulus

nervous system

nervous system phenotype ( J:255928 )

N • morphology of retinal cells, axons and dendrites

Genotype
MGI:5780462

hm2

• Allelic Composition: Cabp1^tm1Alee/Cabp1^tm1Alee
• Genetic Background: involves: 129 * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:210321 )

• homozygotes are viable and fertile and display normal survival and body weight with no apparent physiological or motor deficits