Phenotypes associated with this allele

• Allele Symbol: Mlc1^tm1.2Nune
• Allele Name: targeted mutation 1.2, Virginia Nunes
• Allele ID: MGI:5618264
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlc1^tm1.2Nune/Mlc1^tm1.2Nune	involves: 129 * C57BL/6	MGI:5646501

Genotype
MGI:5646501

hm1

• Allelic Composition: Mlc1^tm1.2Nune/Mlc1^tm1.2Nune
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

brain vacuoles ( J:210308 )

• myelin vacuolization that slowly progresses with age

abnormal myelin sheath morphology ( J:210308 )

• myelin vacuolization that slowly progresses with age

• most prominent in fibre tracts of the cerebellum

• vacuolization is largely restricted to the cerebellum even after 1 year of age

• leukodystrophy

abnormal glial cell physiology ( J:210308 )

• abnormal Cl- currents in Bergmann glia

• cell capacitance is increased in Bergmann glia

• current amplitudes normalized to cell capacitance are moderately smaller compared to controls in Bergmann glia

abnormal oligodendrocyte physiology ( J:210308 )

• membrane capacitance is increased