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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdh5tm5Dvst
targeted mutation 5, Dietmar Vestweber
MGI:5617005
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cdh5tm5Dvst/Cdh5tm5Dvst B6.Cg-Cdh5tm5Dvst MGI:5697964


Genotype
MGI:5697964
hm1
Allelic
Composition		 Cdh5tm5Dvst/Cdh5tm5Dvst
Genetic
Background		 B6.Cg-Cdh5tm5Dvst
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh5tm5Dvst mutation (0 available); any Cdh5 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cellular extravasation ( J:209801 )
• extravasation of Evans Blue Dye blocked in mice stimulated with VEGF or histamine
• reduced leakage of fluorescent microspheres from vessels after stimulation with VEGF or histamine
• very slightly enhanced IL-1Beta induced extravasation of neutrophiles

hematopoietic system
abnormal cellular extravasation ( J:209801 )
• extravasation of Evans Blue Dye blocked in mice stimulated with VEGF or histamine
• reduced leakage of fluorescent microspheres from vessels after stimulation with VEGF or histamine
• very slightly enhanced IL-1Beta induced extravasation of neutrophiles

immune system
abnormal cellular extravasation ( J:209801 )
• extravasation of Evans Blue Dye blocked in mice stimulated with VEGF or histamine
• reduced leakage of fluorescent microspheres from vessels after stimulation with VEGF or histamine
• very slightly enhanced IL-1Beta induced extravasation of neutrophiles




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory