All Phenotypes Mbnl2<tm1Sws> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mbnl2^tm1Sws
targeted mutation 1, Maurice W Swanson
MGI:5616743

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mbnl1^tm1Sws/Mbnl1^tm1Sws Mbnl2^tm1Sws/Mbnl2^tm1Sws Tg(Myog-cre)1Eno/0	involves: 129S1/Sv * 129S1/SvImJ * C57BL	MGI:5616749

Allelic Composition	Mbnl1^tm1Sws/Mbnl1^tm1Sws Mbnl2^tm1Sws/Mbnl2^tm1Sws Tg(Myog-cre)1Eno/0
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbnl1^tm1Sws mutation (2 available); any Mbnl1 mutation (38 available)
Mbnl2^tm1Sws mutation (0 available); any Mbnl2 mutation (66 available)
Tg(Myog-cre)1Eno mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased birth body size ( J:218011 )

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:218011 )

• develop severe motor deficits beginning at 12 weeks of age

decreased grip strength ( J:218011 )

skeleton

kyphosis ( J:218011 )

• develop kyphosis beginning at 12 weeks of age

muscle

decreased skeletal muscle fiber size ( J:218011 )

increased variability of skeletal muscle fiber size ( J:218011 )

centrally nucleated skeletal muscle fibers ( J:218011 )

skeletal muscle degeneration ( J:218011 )

• profound deficiency of adult skeletal muscle, with severe muscle pathology including small myofibers, fiber size heterogeneity, and centralized nuclei in nearly all myofibers

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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