Phenotypes associated with this allele

• Allele Symbol: Smg9^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:5616624
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smg9^em1(IMPC)J/Smg9^em1(IMPC)J	C57BL/6NJ-Smg9^em1(IMPC)J/J	MGI:6263532
hm2	Smg9^em1(IMPC)J/Smg9^em1(IMPC)J	involves: C57BL/6NJ	MGI:5776357
ht3	Smg9^em1(IMPC)J/Smg9^+	C57BL/6NJ-Smg9^em1(IMPC)J/J	MGI:6263531

Genotype
MGI:6263532

hm1

• Allelic Composition: Smg9^em1(IMPC)J/Smg9^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Smg9^em1(IMPC)J/J

Data Sources

IMPC Data for Smg9

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryo size ( J:211773 )

IMPC - JAX

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - JAX

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

nervous system

exencephaly ( J:211773 )

IMPC - JAX

Genotype
MGI:5776357

hm2

• Allelic Composition: Smg9^em1(IMPC)J/Smg9^em1(IMPC)J
• Genetic Background: involves: C57BL/6NJ

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:231968 )

postnatal lethality, complete penetrance ( J:231968 )

• no pups are produced from breeding heterozygous mice

cardiovascular system

thin myocardium ( J:231968 )

atrioventricular septal defect ( J:231968 )

hemorrhage ( J:231968 )

• variable with incompletely penetrance at E15.5

• in two mice at E18.5

nervous system

decreased hindbrain size ( J:231968 )

decreased midbrain size ( J:231968 )

exencephaly ( J:231968 )

• variable with incompletely penetrance at E15.5

growth/size/body

decreased fetal size ( J:231968 )

fetal growth retardation ( J:231968 )

vision/eye

microphthalmia ( J:231968 )

homeostasis/metabolism

edema ( J:231968 )

• variable with incompletely penetrance at E15.5

• variable in two mice at E18.5

limbs/digits/tail

preaxial polydactyly ( J:231968 )

muscle

thin myocardium ( J:231968 )

Genotype
MGI:6263531

ht3

• Allelic Composition: Smg9^em1(IMPC)J/Smg9⁺
• Genetic Background: C57BL/6NJ-Smg9^em1(IMPC)J/J

Data Sources

IMPC Data for Smg9

behavior/neurological

abnormal behavior ( J:211773 )

♂

IMPC - JAX

decreased thigmotaxis ( J:211773 )

♂

IMPC - JAX

hyperactivity ( J:211773 )

♂

IMPC - JAX

embryo

abnormal embryo size ( J:211773 )

IMPC - JAX

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - JAX

hematopoietic system

decreased mean corpuscular hemoglobin concentration ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

IMPC - JAX