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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Casp8tm1.1Vmd
targeted mutation 1.1, Vishva M Dixit
MGI:5614580
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Casp8tm1.1Vmd/Casp8tm1.1Vmd involves: C57BL/6N MGI:5614614
cx2
 		Casp8tm1.1Vmd/Casp8tm1.1Vmd
Ripk3tm2Vmd/Ripk3tm2Vmd 		involves: C57BL/6N MGI:5614616
cx3
 		Casp8tm1.1Vmd/Casp8+
Ripk3tm2Vmd/Ripk3tm2Vmd 		involves: C57BL/6N MGI:5614618


Genotype
MGI:5614614
hm1
Allelic
Composition		 Casp8tm1.1Vmd/Casp8tm1.1Vmd
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8tm1.1Vmd mutation (0 available); any Casp8 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:209137 )
• embryos die mid-gestation




Genotype
MGI:5614616
cx2
Allelic
Composition		 Casp8tm1.1Vmd/Casp8tm1.1Vmd
Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8tm1.1Vmd mutation (0 available); any Casp8 mutation (45 available)
Ripk3tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased T cell number ( J:209137 )
• accumulation of T cells expressing the surface markers CD3 and B220
• T cells, however, proliferate normally in response to antibodies to CD3 and CD28

immune system
increased T cell number ( J:209137 )
• accumulation of T cells expressing the surface markers CD3 and B220
• T cells, however, proliferate normally in response to antibodies to CD3 and CD28

mortality/aging
mortality/aging ( J:209137 )
N
• mice are viable

growth/size/body
enlarged spleen ( J:209137 )




Genotype
MGI:5614618
cx3
Allelic
Composition		 Casp8tm1.1Vmd/Casp8+
Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8tm1.1Vmd mutation (0 available); any Casp8 mutation (45 available)
Ripk3tm2Vmd mutation (0 available); any Ripk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory