Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-TNNI3K)#Tfo
• Allele Name: transgene insertion, Thomas Force
• Allele ID: MGI:5614260
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-TNNI3K)#Tfo/0	involves: FVB/N	MGI:5614266

Genotype
MGI:5614266

tg1

• Allelic Composition: Tg(Myh6-TNNI3K)#Tfo/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:213546 )

N • mice exhibit normal basal left ventricle function, cardiac morphometry, contractile function

abnormal myocardial fiber physiology ( J:213546 )

• increased cell death following ischemic/reperfusion injury

abnormal response to cardiac infarction ( J:213546 )

• following ischemic/reperfusion injury, mice exhibit increased infarct size, superoxide levels and cardiomyocyte cell death compared with wild-type mice

increased myocardial infarct size ( J:213546 )

• following ischemic/reperfusion injury

• however, treatment with SB239063 (a selective p38/Mapk14 inhibitor) decreased size

cellular

oxidative stress ( J:213546 )

• basal and post-ischemic/reperfusion injury superoxide levels are increased compared with wild-type mice

homeostasis/metabolism

abnormal response to cardiac infarction ( J:213546 )

• following ischemic/reperfusion injury, mice exhibit increased infarct size, superoxide levels and cardiomyocyte cell death compared with wild-type mice

increased myocardial infarct size ( J:213546 )

• following ischemic/reperfusion injury

• however, treatment with SB239063 (a selective p38/Mapk14 inhibitor) decreased size