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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gnai2tm2.1Rneu
targeted mutation 2.1, Richard R Neubig
MGI:5614236
Summary 2 genotypes


Genotype
MGI:5614492
hm1
Allelic
Composition		 Gnai2tm2.1Rneu/Gnai2tm2.1Rneu
Genetic
Background		 B6.129(Cg)-Gnai2tm2.1Rneu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2tm2.1Rneu mutation (1 available); any Gnai2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:217517 )
• mice are viable and fertile




Genotype
MGI:5614488
cn2
Allelic
Composition		 Gnai2tm2.1Rneu/Gnai2tm2.1Rneu
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic
Background		 B6.Cg-Gt(ROSA)26Sortm1(cre/ert2)Tyj Gnai2tm2.1Rneu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2tm2.1Rneu mutation (1 available); any Gnai2 mutation (52 available)
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (6 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal response to cardiac infarction ( J:217517 )
• postischemic recovery of +dP/dT and -dP/dT is enhanced in hearts from tamoxifen treated animals as compared to controls
• postischemic recovery of developed pressure is enhanced in hearts from tamoxifen treated animals as compared to controls
decreased myocardial infarct size ( J:217517 )
• following tamoxifen administration, ischemia-induced myocardial infarct size is decreased as compared to controls

homeostasis/metabolism
abnormal response to cardiac infarction ( J:217517 )
• postischemic recovery of +dP/dT and -dP/dT is enhanced in hearts from tamoxifen treated animals as compared to controls
• postischemic recovery of developed pressure is enhanced in hearts from tamoxifen treated animals as compared to controls
decreased myocardial infarct size ( J:217517 )
• following tamoxifen administration, ischemia-induced myocardial infarct size is decreased as compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory