Phenotypes associated with this allele

• Allele Symbol: Osbp2^tm1Arai
• Allele Name: targeted mutation 1, Hiroyuki Arai
• Allele ID: MGI:5613891
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Osbp2^tm1Arai/Osbp2^tm1Arai	C57BL/6-Osbp2^tm1Arai	MGI:5613900

Genotype
MGI:5613900

hm1

• Allelic Composition: Osbp2^tm1Arai/Osbp2^tm1Arai
• Genetic Background: C57BL/6-Osbp2^tm1Arai

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:215726 )

N • female mice exhibit normal fecundity

N • male mice exhibit normal mating behavior and ejaculation

N • spermatogonia exhibit normal proliferation

oligozoospermia ( J:215726 )

♂

teratozoospermia ( J:215726 )

♂

abnormal sperm mitochondrial sheath morphology ( J:215726 )

♂ • coiling around irregular round heads

absent sperm mitochondrial sheath ( J:215726 )

♂ • in most spermatozoa in cauda epididymides

abnormal sperm head morphology ( J:215726 )

♂ • irregularly shaped heads, including round-shaped and curled back heads

abnormal acrosome morphology ( J:215726 )

♂ • with unusual features such as bleb-like structures

globozoospermia ( J:215726 )

♂

abnormal spermatid morphology ( J:215726 )

♂ • abnormal elongating and elongated spermatids

abnormal male germ cell apoptosis ( J:215726 )

♂ • especially of elongated spermatids with flagellum

asthenozoospermia ( J:215726 )

♂

abnormal spermiogenesis ( J:215726 )

♂ • impaired detaching and removal of cytoplasm from the sperm head

increased Sertoli cell phagocytosis ( J:215726 )

♂

male infertility ( J:215726 )

♂

impaired fertilization ( J:215726 )

♂ • no fertilization in vitro using sperm

♂ • however, direct injection of sperm into oocytes results in normal cleavage, implantation and birth rates

cellular

oligozoospermia ( J:215726 )

♂

teratozoospermia ( J:215726 )

♂

abnormal sperm mitochondrial sheath morphology ( J:215726 )

♂ • coiling around irregular round heads

absent sperm mitochondrial sheath ( J:215726 )

♂ • in most spermatozoa in cauda epididymides

abnormal sperm head morphology ( J:215726 )

♂ • irregularly shaped heads, including round-shaped and curled back heads

abnormal acrosome morphology ( J:215726 )

♂ • with unusual features such as bleb-like structures

globozoospermia ( J:215726 )

♂

abnormal spermatid morphology ( J:215726 )

♂ • abnormal elongating and elongated spermatids

abnormal male germ cell apoptosis ( J:215726 )

♂ • especially of elongated spermatids with flagellum

asthenozoospermia ( J:215726 )

♂