Phenotypes associated with this allele

• Allele Symbol: Rpgr^tm1.1Sgj
• Allele Name: targeted mutation 1.1, Samuel G Jacobson
• Allele ID: MGI:5610131
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rpgr^tm1.1Sgj/Rpgr^tm1.1Sgj	involves: 129 * BALB/c	MGI:5610133
ot2	Rpgr^tm1.1Sgj/Y	involves: 129 * BALB/c	MGI:5610134

Genotype
MGI:5610133

hm1

• Allelic Composition: Rpgr^tm1.1Sgj/Rpgr^tm1.1Sgj
• Genetic Background: involves: 129 * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

thin retina outer nuclear layer ( J:213970 )

♀ • some at 5 to 6 months

♀ • pronounced at 13 months

♀ • inferior thickness is less than superior

retina degeneration ( J:213970 )

♀ • hyperreflective vitreoretinal interface in optical coherence topology scans

abnormal cone electrophysiology ( J:213970 )

♀ • reduced cone electroretinogram at 5 to 7 and 11 to 13 months

♀ • absent cone electroretinogram in older mice

abnormal rod electrophysiology ( J:213970 )

♀ • reduced amplitudes in dark-adapted electroretinogram at 5 to 7 months at higher stimulus intensities

♀ • further reduced amplitudes at 11 to 13 months

Genotype
MGI:5610134

ot2

• Allelic Composition: Rpgr^tm1.1Sgj/Y
• Genetic Background: involves: 129 * BALB/c

vision/eye

thin retina outer nuclear layer ( J:213970 )

♂ • some at 5 to 6 months

♂ • pronounced at 13 months

♂ • inferior thickness is less than superior

retina degeneration ( J:213970 )

♂ • hyperreflective vitreoretinal interface in optical coherence topology scans

abnormal cone electrophysiology ( J:213970 )

♂ • reduced cone electroretinogram at 5 to 7 and 11 to 13 months

♂ • absent cone electroretinogram in older mice

abnormal rod electrophysiology ( J:213970 )

♂ • reduced amplitudes in dark-adapted electroretinogram at 5 to 7 months at higher stimulus intensities

♂ • further reduced amplitudes at 11 to 13 months