About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igktm1(IGK)Vlcg
targeted mutation 1, Velocigene
MGI:5610003
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ightm1(IGH)Vlcg/Ightm1(IGH)Vlcg
Igktm1(IGK)Vlcg/Igktm1(IGK)Vlcg 		involves: 129S6/SvEvTac * C57BL/6N MGI:5610008


Genotype
MGI:5610008
cx1
Allelic
Composition		 Ightm1(IGH)Vlcg/Ightm1(IGH)Vlcg
Igktm1(IGK)Vlcg/Igktm1(IGK)Vlcg
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1(IGH)Vlcg mutation (0 available); any Igh mutation (43 available)
Igktm1(IGK)Vlcg mutation (0 available); any Igk mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced male fertility ( J:208619 )
• restoring expression of Adam6a and Adam6b restores male fertility

immune system
immune system phenotype ( J:208620 )
N
• normal numbers of B cells, normal lambda/kappa ratios, and secondary lymphoid organs appear similar to controls
• produce humanized antibodies following immunization




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory