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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm2(IGH)Vlcg
targeted mutation 2, Velocigene
MGI:5609987
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm2(IGH)Vlcg/Ightm2(IGH)Vlcg involves: 129S6/SvEvTac * C57BL/6N MGI:5610009
cx2
 		Ightm2(IGH)Vlcg/Ightm2(IGH)Vlcg
Igktm2(IGK)Vlcg/Igktm2(IGK)Vlcg 		involves: 129S6/SvEvTac * C57BL/6N MGI:5610010


Genotype
MGI:5610009
hm1
Allelic
Composition		 Ightm2(IGH)Vlcg/Ightm2(IGH)Vlcg
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2(IGH)Vlcg mutation (0 available); any Igh mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced male fertility ( J:208619 )
• restoring expression of Adam6a and Adam6b restores male fertility




Genotype
MGI:5610010
cx2
Allelic
Composition		 Ightm2(IGH)Vlcg/Ightm2(IGH)Vlcg
Igktm2(IGK)Vlcg/Igktm2(IGK)Vlcg
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2(IGH)Vlcg mutation (0 available); any Igh mutation (45 available)
Igktm2(IGK)Vlcg mutation (0 available); any Igk mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced male fertility ( J:208619 )
• restoring expression of Adam6a and Adam6b restores male fertility

immune system
immune system phenotype ( J:208620 )
N
• normal numbers of B cells, normal lambda/kappa ratios, and secondary lymphoid organs appear similar to controls
• produce humanized antibodies following immunization




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory