All Phenotypes Gpr156<tm1.1(KOMP)Vlcg> MGI Mouse

behavior/neurological

• in the tail suspension test, mice exhibit a hypermobile phenotype, spending more time struggling than controls, struggling for 219.6 sec compared to 149.7 sec in wild-type mice

behavioral despair ( J:373573 )

• in the forced swim test, mice exhibit hypermobility during 20 to 210 sec of vigorous swimming before diving erratically beneath the waters surface in a disorganized and maladaptive manner and had to be rescued from drowning once they start diving; only 14% of mice can swim 6 min without rescue

• however, mice behave similar to wild-type mice in tests for motor coordination, balance, activity, and locomotion

increased anxiety-related response ( J:373573 )

• in the light-dark box test, mice enter the bright zone less frequently and spend less time there

increased thigmotaxis ( J:373573 )

• in the elevated plus maze, mice exhibit 73% less open arm exploration compared to wild-type mice

increased startle reflex ( J:373573 )

• mice have nearly double the startle response of wild-type mice

nervous system

abnormal nervous system electrophysiology ( J:373573 )

• medial habenula neurons have a slightly depolarized resting membrane potential compared to controls

• no differences in other passive membrane properties or excitatory postsynaptic potentials are seen

abnormal action potential ( J:373573 )

• average tonic medial habenula neuron firing is higher than in wild-type brain

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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