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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ifitm5tm1Nha
targeted mutation 1, Nobutaka Hanagata
MGI:5608595
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ifitm5tm1Nha/Ifitm5tm1Nha C57BL/6-Ifitm5tm1Nha MGI:5608596


Genotype
MGI:5608596
hm1
Allelic
Composition
Ifitm5tm1Nha/Ifitm5tm1Nha
Genetic
Background
C57BL/6-Ifitm5tm1Nha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifitm5tm1Nha mutation (0 available); any Ifitm5 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some offspring from intercrosses of homozygous mice die within 48 hours
• fewer than the expected numbers (only 7% vs. the expected 25%) of homozygotes are seen
• fewer females are seen than males (2 of 8 were female)

reproductive system
• intercrosses of homozygotes result in an average of 1.0 pup per litter

skeleton
• skeletons of newborns are shorter
• newborns exhibit thinner craniums
• however, no difference in cranium size is seen in 40-51 week old mutants
• thinner frontal bone in newborns
• newborns exhibit less calcification in the mandible
• however, no differences in mandible are seen in 40-51 week old mutants
• newborns exhibit less calcification in incisive bones and cranial incisors
• however, these differences are no longer seen in 40-51 week old mice
• radius is often severely bent in newborns
• however, this bending is no longer obvious in adults
• ulna is often severely bent in newborns
• however, this bending is no longer obvious in adults
• tibia is often severely bent in newborns
• however, this bending is no longer obvious in adults
• trabecular bones of the tibia do not differ from controls
• clavicles are bent, often severely, in newborns
• however, this bending is no longer obvious is adults
• smaller clavicles in newborns
• long bones are about 15-25% shorter in newborns, with both the metaphysis and diaphysis reduced in length
• long bones are 4-12% shorter in 40 to 51 week old mutants
• smaller iliac bodies in newborns
• iliac bodies are bent, often severely, in newborns
• however, this bending is no longer obvious is adults

craniofacial
• newborns exhibit thinner craniums
• however, no difference in cranium size is seen in 40-51 week old mutants
• thinner frontal bone in newborns
• newborns exhibit less calcification in the mandible
• however, no differences in mandible are seen in 40-51 week old mutants
• newborns exhibit less calcification in incisive bones and cranial incisors
• however, these differences are no longer seen in 40-51 week old mice

limbs/digits/tail
• radius is often severely bent in newborns
• however, this bending is no longer obvious in adults
• ulna is often severely bent in newborns
• however, this bending is no longer obvious in adults
• tibia is often severely bent in newborns
• however, this bending is no longer obvious in adults
• trabecular bones of the tibia do not differ from controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory