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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otx2tm10Sia
targeted mutation 10, Shinichi Aizawa
MGI:5608496
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Otx2tm10Sia/Otx2tm10Sia involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5608499
ht2
 		Otx2tm1Sia/Otx2tm10Sia involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5608500
cx3
 		Otx1tm1Sia/Otx1tm1Sia
Otx2tm10Sia/Otx2tm10Sia 		involves: C57BL/6NCrlj * CBA/JNCrlj MGI:5608501


Genotype
MGI:5608499
hm1
Allelic
Composition		 Otx2tm10Sia/Otx2tm10Sia
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm10Sia mutation (0 available); any Otx2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal embryonic neuroepithelium morphology ( J:207608 )
• diencephalic and mesencephalic regions are reduced
• reduction is more severe than in mice homozygous for Otx2tm9Sia

embryo
abnormal embryonic neuroepithelium morphology ( J:207608 )
• diencephalic and mesencephalic regions are reduced
• reduction is more severe than in mice homozygous for Otx2tm9Sia




Genotype
MGI:5608500
ht2
Allelic
Composition		 Otx2tm1Sia/Otx2tm10Sia
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm10Sia mutation (0 available); any Otx2 mutation (51 available)
Otx2tm1Sia mutation (1 available); any Otx2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal embryonic neuroepithelium morphology ( J:207608 )
• diencephalic and mesencephalic regions are reduced
• phenotype is variable with the most severely affected embryos lacking almost the entire anterior neuroectoderm
abnormal forebrain morphology ( J:207608 )
• small telencephalic vesicle at E9.5
• reduction is more severe than in mice homozygous for Otx2tm10Sia

embryo
abnormal embryonic neuroepithelium morphology ( J:207608 )
• diencephalic and mesencephalic regions are reduced
• phenotype is variable with the most severely affected embryos lacking almost the entire anterior neuroectoderm




Genotype
MGI:5608501
cx3
Allelic
Composition		 Otx1tm1Sia/Otx1tm1Sia
Otx2tm10Sia/Otx2tm10Sia
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx1tm1Sia mutation (1 available); any Otx1 mutation (88 available)
Otx2tm10Sia mutation (0 available); any Otx2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal embryonic neuroepithelium morphology ( J:207608 )
• diencephalic and mesencephalic regions are reduced
• no significant enhancement of the phenotype compared to mice for homozygous for Otx2tm10Sia alone

embryo
abnormal embryonic neuroepithelium morphology ( J:207608 )
• diencephalic and mesencephalic regions are reduced
• no significant enhancement of the phenotype compared to mice for homozygous for Otx2tm10Sia alone




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory