All Phenotypes Otx2<tm10Sia> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Otx2^tm10Sia
targeted mutation 10, Shinichi Aizawa
MGI:5608496

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx2^tm10Sia/Otx2^tm10Sia	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5608499
ht2	Otx2^tm1Sia/Otx2^tm10Sia	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5608500
cx3	Otx1^tm1Sia/Otx1^tm1Sia Otx2^tm10Sia/Otx2^tm10Sia	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5608501

Allelic Composition	Otx2^tm10Sia/Otx2^tm10Sia
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm10Sia mutation (0 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal embryonic neuroepithelium morphology ( J:207608 )

• diencephalic and mesencephalic regions are reduced

• reduction is more severe than in mice homozygous for Otx2^tm9Sia

abnormal forebrain morphology ( J:207608 )

embryo

abnormal embryonic neuroepithelium morphology ( J:207608 )

• diencephalic and mesencephalic regions are reduced

• reduction is more severe than in mice homozygous for Otx2^tm9Sia

Allelic Composition	Otx2^tm1Sia/Otx2^tm10Sia
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm10Sia mutation (0 available); any Otx2 mutation (50 available)
Otx2^tm1Sia mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal embryonic neuroepithelium morphology ( J:207608 )

• diencephalic and mesencephalic regions are reduced

• phenotype is variable with the most severely affected embryos lacking almost the entire anterior neuroectoderm

abnormal forebrain morphology ( J:207608 )

• small telencephalic vesicle at E9.5

• reduction is more severe than in mice homozygous for Otx2^tm10Sia

embryo

abnormal embryonic neuroepithelium morphology ( J:207608 )

• diencephalic and mesencephalic regions are reduced

• phenotype is variable with the most severely affected embryos lacking almost the entire anterior neuroectoderm

Allelic Composition	Otx1^tm1Sia/Otx1^tm1Sia Otx2^tm10Sia/Otx2^tm10Sia
Genetic Background	involves: C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx1^tm1Sia mutation (1 available); any Otx1 mutation (86 available)
Otx2^tm10Sia mutation (0 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal embryonic neuroepithelium morphology ( J:207608 )

• diencephalic and mesencephalic regions are reduced

• no significant enhancement of the phenotype compared to mice for homozygous for Otx2^tm10Sia alone

embryo

abnormal embryonic neuroepithelium morphology ( J:207608 )

• diencephalic and mesencephalic regions are reduced

• no significant enhancement of the phenotype compared to mice for homozygous for Otx2^tm10Sia alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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