Phenotypes associated with this allele

• Allele Symbol: Fas^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5607750
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fas^m1Btlr/Fas^m1Btlr	C57BL/6J-Fas^m1Btlr	MGI:5607751

Genotype
MGI:5607751

hm1

• Allelic Composition: Fas^m1Btlr/Fas^m1Btlr
• Genetic Background: C57BL/6J-Fas^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased neutrophil cell number ( J:216052 )

• mice homozygous for this mutation exhibit an elevated frequency of neutrophils in the peripheral blood.

increased NK cell number ( J:216052 )

• homozygous mutant mice exhibit an elevated frequency of natural killer (NK) cells in the peripheral blood.

decreased CD4-positive, alpha-beta T cell number ( J:216052 )

• homozygous mutant mice exhibit a reduced frequency of CD4⁺ alpha beta T lymphocytes in the periphery.

decreased CD8-positive, alpha-beta T cell number ( J:216052 )

• homozygous mutant mice exhibit a reduced frequency of peripheral CD8⁺ alpha beta T lymphocytes.

immune system

increased neutrophil cell number ( J:216052 )

• mice homozygous for this mutation exhibit an elevated frequency of neutrophils in the peripheral blood.

increased NK cell number ( J:216052 )

• homozygous mutant mice exhibit an elevated frequency of natural killer (NK) cells in the peripheral blood.

decreased CD4-positive, alpha-beta T cell number ( J:216052 )

• homozygous mutant mice exhibit a reduced frequency of CD4⁺ alpha beta T lymphocytes in the periphery.

decreased CD8-positive, alpha-beta T cell number ( J:216052 )

• homozygous mutant mice exhibit a reduced frequency of peripheral CD8⁺ alpha beta T lymphocytes.