Phenotypes associated with this allele

• Allele Symbol: Nlrp3^M7Btlr
• Allele Name: mutation 7, Bruce Beutler
• Allele ID: MGI:5607730
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlrp3^M7Btlr/Nlrp3^M7Btlr	C57BL/6J-Nlrp3^M7Btlr	MGI:5608879
ht2	Nlrp3^M7Btlr/Nlrp3^+	C57BL/6J-Nlrp3^M7Btlr	MGI:5608884

Genotype
MGI:5608879

hm1

• Allelic Composition: Nlrp3^M7Btlr/Nlrp3^M7Btlr
• Genetic Background: C57BL/6J-Nlrp3^M7Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage cytokine production ( J:216048 )

• thioglycolate-elicited peritoneal macrophages from mice bearing this mutation secrete less interleukin-1 beta than do cells of control mice in response to priming with bacterial lipopolysaccharide (LPS) followed by nigericin treatment; IL-1 beta secretion by heterozygous mutant macrophages is intermediate between homozygous and wild-type levels.

decreased interleukin-1 beta secretion ( J:216048 )

• thioglycolate-elicited peritoneal macrophages from mice bearing this mutation secrete less interleukin-1 beta than do cells of control mice in response to priming with bacterial lipopolysaccharide (LPS) followed by nigericin treatment; IL-1 beta secretion by heterozygous mutant macrophages is intermediate between homozygous and wild-type levels.

hematopoietic system

abnormal macrophage cytokine production ( J:216048 )

• thioglycolate-elicited peritoneal macrophages from mice bearing this mutation secrete less interleukin-1 beta than do cells of control mice in response to priming with bacterial lipopolysaccharide (LPS) followed by nigericin treatment; IL-1 beta secretion by heterozygous mutant macrophages is intermediate between homozygous and wild-type levels.

Genotype
MGI:5608884

ht2

• Allelic Composition: Nlrp3^M7Btlr/Nlrp3⁺
• Genetic Background: C57BL/6J-Nlrp3^M7Btlr

immune system

abnormal macrophage cytokine production ( J:216048 )

• thioglycolate-elicited peritoneal macrophages from mice bearing this mutation secrete less interleukin-1 beta than do cells of control mice in response to priming with bacterial lipopolysaccharide (LPS) followed by nigericin treatment; IL-1 beta secretion by heterozygous mutant macrophages is intermediate between homozygous and wild-type levels.

decreased interleukin-1 beta secretion ( J:216048 )

• thioglycolate-elicited peritoneal macrophages from mice bearing this mutation secrete less interleukin-1 beta than do cells of control mice in response to priming with bacterial lipopolysaccharide (LPS) followed by nigericin treatment; IL-1 beta secretion by heterozygous mutant macrophages is intermediate between homozygous and wild-type levels.

hematopoietic system

abnormal macrophage cytokine production ( J:216048 )

• thioglycolate-elicited peritoneal macrophages from mice bearing this mutation secrete less interleukin-1 beta than do cells of control mice in response to priming with bacterial lipopolysaccharide (LPS) followed by nigericin treatment; IL-1 beta secretion by heterozygous mutant macrophages is intermediate between homozygous and wild-type levels.