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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ern2m1Btlr
mutation 1, Bruce Beutler
MGI:5607643
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ern2m1Btlr/Ern2m1Btlr C57BL/6J-Ern2m1Btlr MGI:5607644


Genotype
MGI:5607644
hm1
Allelic
Composition		 Ern2m1Btlr/Ern2m1Btlr
Genetic
Background		 C57BL/6J-Ern2m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ern2m1Btlr mutation (1 available); any Ern2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased susceptibility to induced colitis ( J:216045 )
• mice homozygous for this mutation exhibit weight loss at day 7 and day 10 after treatment with dextran sulfate sodium (DSS)-containing water, indicative of susceptibility to DSS-induced colitis.

immune system
increased susceptibility to induced colitis ( J:216045 )
• mice homozygous for this mutation exhibit weight loss at day 7 and day 10 after treatment with dextran sulfate sodium (DSS)-containing water, indicative of susceptibility to DSS-induced colitis.




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory