Analysis Tools
normal phenotype
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• homozygotes appear to develop normally
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Allele Symbol Allele Name Allele ID |
Diaph2tm1.2Sna targeted mutation 1.2, Shuh Narumiya MGI:5606179 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes appear to develop normally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• layer formation in the somatosensory cortex is normal
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• fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)
• doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end
• double cortin positive cells are disorganized on the lateral ventricle wall before migration
• migration of cells out of explants cultured in Matrigel is reduced
• migration of cells is slower
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• fewer GABA cells in the cerebral cortex at E16.5
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• marked loss of granule cells in adults
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• reduced in size whereas brain size is normal
|
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• fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)
• doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end
• double cortin positive cells are disorganized on the lateral ventricle wall before migration
• migration of cells out of explants cultured in Matrigel is reduced
• migration of cells is slower
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• layer formation in the somatosensory cortex is normal
|
|
|
• fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)
• doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end
• double cortin positive cells are disorganized on the lateral ventricle wall before migration
• migration of cells out of explants cultured in Matrigel is reduced
• migration of cells is slower
|
|
|
• fewer GABA cells in the cerebral cortex at E16.5
|
|
|
• marked loss of granule cells in adults
|
|
|
• reduced in size whereas brain size is normal
|
|
|
• fewer GAD65 and GAD67 positive cells enter the pallium and top of the cerebral cortex at E14.5 (impaired tangential migration of cortical inhibitory interneuron precursors)
• doublecortin positive subventricular zone cells at higher levels at the posterior of the rostral migratory stream than at the anterior end
• double cortin positive cells are disorganized on the lateral ventricle wall before migration
• migration of cells out of explants cultured in Matrigel is reduced
• migration of cells is slower
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
• homozygotes appear to develop normally
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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