Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm3.1Swch mutation
(0 available);
any
Ryr2 mutation
(325 available)
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mortality/aging
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• embryonic lethal, time not specified
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Allelic Composition |
Ryr2tm3.1Swch/Ryr2+
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm3.1Swch mutation
(0 available);
any
Ryr2 mutation
(325 available)
|
|
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cardiovascular system
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• the time-to-peak and time-to-50% decay of calcium release evoked by depolarization is slightly, but significantly, increased in cardiomyocytes
• however, mice do not exhibit stress-induced (by caffeine or epinephrine) ventricular tachyarrhythmias at young or older ages
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mortality/aging
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• mice die starting around 11 days post tamoxifen injection, with most dying by day 14
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cardiovascular system
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• 12 days post tamoxifen treatment, mice exhibit a reduced basal heart rate
• tamoxifen treated mice, however, do not exhibit stress-induced (by caffeine or epinephrine) ventricular tachyarrhythmias at young or older ages
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