Phenotypes associated with this allele

• Allele Symbol: Atg16l1^tm1.1Mvlc
• Allele Name: targeted mutation 1.1, Menno van Lookeren Campagne
• Allele ID: MGI:5605964
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atg16l1^tm1.1Mvlc/Atg16l1^tm1.1Mvlc	C57BL/6-Atg16l1^tm1.1Mvlc	MGI:5605966

Genotype
MGI:5605966

hm1

• Allelic Composition: Atg16l1^tm1.1Mvlc/Atg16l1^tm1.1Mvlc
• Genetic Background: C57BL/6-Atg16l1^tm1.1Mvlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:206931 )

N • no overt inflammatory phenotypes in untreated mice

abnormal macrophage physiology ( J:206931 )

• macrophages show impaired clearance of Y. enterocolitica

increased macrophage cytokine production ( J:206931 )

• increase in TNF, IL1B and IL6 in cell media from Y. enterocolitica infected macrophages compared to media from infected wild-type cells

increased circulating interleukin-1 beta level ( J:206931 )

• increase in serum IL1B 48 h after Y. enterocolitica oral gavage

increased susceptibility to bacterial infection ( J:206931 )

• increase in bacterial burden and pro-inflammatory signaling in the mesenteric lymph nodes 48 h after Y. enterocolitica oral gavage

• increase in serum IL1B 48 h after Y. enterocolitica oral gavage

cellular

impaired autophagy ( J:206931 )

• defect in autophagy in nutrient starved macrophages

digestive/alimentary system

digestive/alimentary phenotype ( J:206931 )

N • the morphology of the small intestine and colon are normal in uninfected mice

homeostasis/metabolism

impaired autophagy ( J:206931 )

• defect in autophagy in nutrient starved macrophages

increased circulating interleukin-1 beta level ( J:206931 )

• increase in serum IL1B 48 h after Y. enterocolitica oral gavage

hematopoietic system

abnormal macrophage physiology ( J:206931 )

• macrophages show impaired clearance of Y. enterocolitica

increased macrophage cytokine production ( J:206931 )

• increase in TNF, IL1B and IL6 in cell media from Y. enterocolitica infected macrophages compared to media from infected wild-type cells